Ammonium glycyrrhizate manufacturers

About ammonium glycyrrhizate

Ammonium glycyrrhizate manufacturers include liquorice extract producers such as MAFCO and many Chinese producers, plus Minophagen Pharmaceutical in Japan, which uses it in Stronger Neo-Minophagen C. Ammonium glycyrrhizate is the ammonium salt of glycyrrhizin, the main active compound in liquorice root. It is used in liver medicines in Japan and China, as an anti-inflammatory in skin products, and as a sweetener and flavour. Pharmaceutical companies can source ammonium glycyrrhizate API and finished products through supply or out-licensing.

Ammonium glycyrrhizate key facts

Ammonium glycyrrhizate manufacturers and licensing history

Glycyrrhizin has been used in Japanese medicine for decades. Minophagen Pharmaceutical's Stronger Neo-Minophagen C (SNMC), an intravenous injection, contains monoammonium glycyrrhizinate with glycine and cysteine. It is used for chronic liver disease, and Glycyron tablets provide an oral form.

In China, compound glycyrrhizin injections and tablets based on monoammonium glycyrrhizinate are widely used for liver disease. Many Chinese companies make both the API and the finished products.

Ammonium glycyrrhizate is also a common cosmetic ingredient and a flavour enhancer. MAFCO is a major supplier of liquorice derivatives, including Magnasweet.

Buyers should confirm the grade (pharmaceutical, cosmetic or food), compliance with the Ph. Eur. monograph and GMP status before choosing a supplier.

Ammonium glycyrrhizate dosage forms and dossier types

Ammonium glycyrrhizate is supplied as injections and tablets for liver disease, as an ingredient in topical products and as bulk API.

Ammonium glycyrrhizate regulatory and patent status

Ammonium glycyrrhizate is off-patent and has a Ph. Eur. monograph. Glycyrrhizin injections and tablets are approved medicines in Japan and China. In the EU and US, ammonium glycyrrhizate is used mainly in cosmetics, as an excipient and as a flavour. Labels warn about pseudoaldosteronism, especially at high doses or with diuretics and corticosteroids.

Ammonium glycyrrhizate mechanism of action and therapeutic use

Glycyrrhizin has anti-inflammatory and immune-modulating effects and helps protect liver cells. In Japan and China, it is used to improve liver function in chronic liver disease, including viral hepatitis. On the skin, it is used to soothe irritation. High doses can cause sodium retention and potassium loss, leading to high blood pressure.

Ammonium glycyrrhizate licensing and sourcing

Ammonium glycyrrhizate suppliers and licensing partners typically offer API supply, finished-product supply or dossier out-licensing. Buyers usually compare GMP status, product grade, pharmacopoeial compliance and territory availability. Current offers and supplier contacts are listed among the ammonium glycyrrhizate manufacturers on Pipelinepharma.

Frequently asked questions about ammonium glycyrrhizate

Who are the main ammonium glycyrrhizate manufacturers? Minophagen Pharmaceutical makes SNMC and Glycyron in Japan. Many Chinese companies make compound glycyrrhizin products and API, and MAFCO supplies liquorice derivatives worldwide.

What is the difference between ammonium glycyrrhizate and glycyrrhizin? Glycyrrhizin (glycyrrhizic acid) is the active compound in liquorice root. Ammonium glycyrrhizate is its ammonium salt, which is more stable and easier to formulate.

What is ammonium glycyrrhizate used for? Ammonium glycyrrhizate is used in liver medicines in Japan and China, as an anti-inflammatory in skin products, and as a sweetener and flavour.

Is ammonium glycyrrhizate approved in the EU? Ammonium glycyrrhizate has a Ph. Eur. monograph and is used in cosmetics and as an excipient. No glycyrrhizin liver medicine is approved in the EU.

What are the safety risks of ammonium glycyrrhizate? At high doses, ammonium glycyrrhizate can cause pseudoaldosteronism, with high blood pressure, low potassium and fluid retention.